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British Association of Dermatologists | www.bad.org.uk/leaflets | Registered Charity No. 258474
Mild stomach pain, nausea and diarrhoea are the most common side effects
of colchicine. In most cases, this is not harmful and will resolve when the dose
is reduced.
What are the rare side effects of colchicine?
Overall, with the low doses of colchicine used in skin disease, severe side
effects are rare.
With prolonged use, colchicine can cause a reduction of blood cells, which
may cause anaemia, a tendency to bleed or an inability to fight infection.
Following prolonged use, some thinning of hair may be noticed. All these side
effects resolve after colchicine has been stopped.
Colchicine may damage nerves, causing tingling, reduced sensation, and
muscle weakness. Very rarely patients can be allergic to colchicine and
develop a severe allergic skin rash.
Colchicine poisoning, due to excessive doses, can cause severe abdominal
pain, fever, burning sensations in the throat, abdomen and skin, diarrhoea,
nausea and vomiting, and collapse. Immediate attention should be sought.
How will the side-effects of colchicine treatment be monitored?
Regular blood and urine tests are required, initially monthly, and then every
three months during treatment. Where appropriate, women may be asked to
take a pregnancy test.
Can immunisations (vaccinations) be given whilst using colchicine?
Yes, vaccinations are safe whilst taking colchicine.
Does colchicine affect fertility or pregnancy?
Men taking colchicine may develop a reduced sperm count, which may
reduce their fertility. Women of child-bearing age should use effective
contraception whilst taking colchicine.
Though studies have demonstrated safety in pregnant patients with familial
Mediterranean fever, there is the potential risk of damage to the unborn baby.
In general, colchicine should not be taken during pregnancy. Colchicine is
also present in breast milk, but has not been found to harm the baby.